Haemoglobinopathy diagnosed on HbA1c analysis

Corpuscular Haemolytic Anaemias - Lepore Haemoglobinopathy.

Haemoglobinopathies are hereditary conditions in which the fundamental lesion affects the synthesis rate or the structure of the globin in normal hemoglobin. The synthesis of the polypeptide chains in globin is genetically coded. Clinically, haemoglobinopathies manifest most commonly in the form of hemolytic anemia and, more rarely, cyanosis and polyglobulia. They differ from "acquired haemoglo...

Renal papillary necrosis in sickle-cell haemoglobinopathy.

Neonatal haemoglobinopathy screening in Belgium.

BACKGROUND A neonatal haemoglobinopathy screening programme was implemented in Brussels more than a decade ago and in Liège 5 years ago; the programme was adapted to the local situation. METHODS Neonatal screening for haemoglobinopathies was universal, performed using liquid cord blood and an isoelectric focusing technique. All samples with abnormalities underwent confirmatory testing. Major ...

Haemoglobinopathies and newborn haemoglobinopathy screening in Germany.

Germany has been an immigration country since the early 1950s. In December 2007, 6.7 million non-German citizens lived in the country. However, the total number of citizens with a migration background is 15-20 million, about 9 million of whom come from countries where sickle cell disease and thalassaemias are frequent. In a country with 82 million inhabitants health authorities are not worried ...

Haemoglobinopathy screening: an end to institutional racism?

The NHS Sickle Cell and Thalassaemia Screening Programme was launched in 2004. The objective of the programme is to offer a sickle cell and thalassaemia screening programme to all pregnant women in high prevalence areas in a timely manner, and to facilitate informed decisionmaking. Thomas et al report an action research project, conducted in 1999–2000, investigating the early offer of antenatal...